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Sildenafil improves the outcome of NO by inhibiting phosphodiesterase variety five (PDE5), which can be responsible for degradation of cGMP inside the corpus cavernosum. Sildenafil has no immediate relaxant effect on isolated human corpus cavernosum.irregular eyesight, for example modifications in colour vision (for instance aquiring a blue colorat

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Thus, the metabolite is responsible for about 20% of sildenafil's action. Sildenafil is excreted as metabolites predominantly while in the feces (about eighty% of administered oral dose) also to a lesser extent in the urine (around 13% on the administered oral dose). If taken which has a higher-Unwanted fat food, absorption is minimized; enough tim

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